Assessment of Body Burden in Man
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چکیده
Historically, plutonium still may be considered a material of very recent vintage, having been discovered only 24 years ago by Seaborg, McMillan, Kennedy, and Wahl [1]. Within a few months 239 after discovery, the fissionable properties of the Pu isotope were established by the same group using an amount of material (0.5 Bg) equal to what is now considered to be approximately one maximum permissible body burden. In late 1942, Hamilton and coworkers [2] began studying the assimilation, distribution, and excretion of fission products and the heavy elements. Short ly thereafter, they observed that plutonium deposited in the bones of rats and postulated its similarity to radium in the production of bone sarcoma. From that time on, plutonium has been considered one of the most toxic substances known. Because of this early recognition of the potentially hazardous nature of plutonium, not one person is known to have been harmed by it other than under
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